Weill Cornell Medicine is seeking a qualified candidate for a full-time Postdoctoral Associate position.

We seek a highly motivated individual to join an academic/pharma drug discovery team. The goal of the project is the development of novel non-opioid antihyperalgesics for the treatment of neuropathic pain. The successful candidate will engage in cutting-edge high-content and high-throughput electrophysiology, molecular modeling and predictive drug design, and nanobody-small molecule conjugation and screening. Demonstrated expertise in at least one of these areas is required. This is at minimum a two-year position, available immediately. This position is supported by NIH funding and will be paid according to NIH pay scale.

We are looking for an outstanding Postdoctoral Associate in New York, NY who can work alongside our experts in ion channel biophysics, molecular biology, neuroscience, and anesthesiology.

Job responsibilities:

• Contribute to conceptual and practical aspects of program strategy
• Use a Sophion automated patch clamp to characterize small molecule inhibitors of human HCN1
• Develop/validate small molecule-protein conjugation strategies - e.g. unnatural amino acid-directed Click chemistry
• Collaborate with internal and external partners to further cryo-EM, molecular modeling and molecular dynamics
• Communicates results to internal stakeholders and external partners through confidential reports and peer reviewed research publications.

Qualifications

Required:

• A PhD in a quantitative field such as biophysics, pharmacology, neuroscience, cellular physiology, or related discipline
• Demonstrated expertise in at least one of electrophysiology, molecular modeling and predictive drug design, and/or nanobody-small molecule conjugation and screening
• Demonstrated scientific excellence as measured by publications and presentations
• Excellent interpersonal, communication, and presentation skills
• Ability to work in a dynamic and collaborative environment
• Excellent attention to detail required

Preferred:

• Expert proficiency in one or more programming languages (such as Python, R, Julia).
• Experience writing re-usable and well-documented code in one or more analytical engines (such as Igor or MATLAB)

How to Apply

• Applicants must submit biographical information, including the expected (or actual) date that they will receive their PhD degree.
• Eligible applicants must have their PhD conferred prior to beginning the position.
• Full CV in PDF format.
• At least one letter of recommendation. Applicants being seriously considered for the position will be invited to participate in an interview (either in person or via electronic conference)

Salary and Appointment Details

• Postdoctoral research associates are provided an annual stipend compliant with the current NIH scale for the first year of the role, and an inflation adjusted salary for year 2 when reappointed.
• This position is for a minimum two-year term with the potential for renewal

Interested candidates should send their CV and cover letter to the attention of:

• Dr. Peter A. Goldstein, MD: pag2014@med.cornell.edu
• Dr. Gareth R. Tibbs, PhD: tibbsga@med.cornell.edu

Weill Cornell Medicine is a comprehensive academic medical center that's committed to excellence in patient care, scientific discovery, and the education of future physicians in New York City and around the world. Our doctors and scientists-faculty from Weill Cornell Medical College, Weill Cornell Graduate School of Medical Sciences, and the Weill Cornell Physician Organization-are engaged in world-class clinical care and cutting-edge research that connect patients to the latest treatment innovations and prevention strategies. Located in the heart of the Upper East Side's scientific corridor, Weill Cornell Medicine's powerful network of collaborators extends to its parent university Cornell University; to Qatar, where an international campus offers a U.S. medical degree; and to programs in Tanzania, Haiti, Brazil, Austria and Turkey. Our medical practices serve communities throughout New York City, and our faculty provide comprehensive care at New York-Presbyterian Hospital/Weill Cornell Medical Center, New York-Presbyterian/Lower Manhattan Hospital, and New York-Presbyterian/Queens. At Weill Cornell Medicine, we work together to treat each individual, not just their conditions or illnesses, as we strive to deliver the finest possible care for our patients - the center of everything we do.

Diversity and Inclusion are a part of Cornell University’s heritage. We are a recognized employer and educator valuing AA/EEO, Protected Veterans and Individuals with Disabilities. We also recognize a lawful preference in employment practices for Native Americans living on or near Indian reservations. Cornell University is an innovative Ivy League university and a great place to work. Our inclusive community of scholars, students, and staff impart an uncommon sense of larger purpose, and contribute creative ideas to further the university's mission of teaching, discovery, and engagement